- Elijah the Hedgehog (deceased father)
- Sarah Rose (mother)
- Amy Rose (sister)
- Celeste the Cat (cousin)
- Sonic the Hedgehog (boyfriend)
- Izzy the Cat (best friend)
- Princess Gala-Su the Hedgehog (best friend)
- Celeste the Cat (best friend)
- Sally the Dog
- Oliver Paterson (close friend)
- Dami the Dog (close friend)
- Threetails the Fox (close friend)
- Topaz the Hedgehog
- Flopii the Hedgehog
- Knuckles the Echidna
- Miles "Tails" Prower
- Cream the Rabbit
- Blaze the Cat
- Silver the Hedgehog
- Shadow the Hedgehog
- Sly the Fox
- Sally Acorn
- Dark Sam (counterpart)
- Dr. Eggman
- Metal Sonic
- Jet the Hawk
- Espio the Chameleon
- Shade the Echidna
- Tiara Boobowski
- Mina Mongoose
- Honey the Cat
Galactic Research Facility
The Galactic Research Facility (abbreviated G.R.F) is a federative group that has investigated the mutation and creating of creatures for years. Sam worked in the team, as an assistant, along with her companions: Aaron Bistle (deceased boss), Oliver Paterson, Tonny Fhitz and Patrick Payton. Sam joins the team again in Sam's Z Mission, but she retires after the death of Aaron there.
AppearanceEarlier, Classic Sam wore a orange-yellow-greenish dress, black shorts and black shoes. In the next generation, Sam wore a blue dress similar to Amy's dress, blue boots and black leggings (she was actually a recolor). Currently, Sam wears a white tank top, black pants, blue shoes, an earring in her ear and special bracelets for an agent.
As stated earlier, Sam is a versatile, agile, beautiful and intelligent agent, but sometimes can be very irritating and smug. She acts sensual to get what she wants in some missions, but Sam really is an adorable, cute and friendly person.
- Beauty and sympathy, two perfect combinations for a loyal and good friend. - Sam's famous quote.
- Huw, are you thinking what I'm thinking? - Sam tells Celeste in The 3 Wacky Girls.
- SLEEPOVER! - Sam's best quote in The 3 Wacky Girls.
- No way! Gimme a break, senior. - Sam discussing with the Government President.
- Flames in Action! - When Sam becomes to Fire Sam in Super Smash Bros. series.
- Can you beat me? - Sam before starting a fight in Super Smash Bros. series.
- Don't call me silly hedgehog! - Sam discussing with Dami.
- I'm the beauty of the track. - Sam starting a sport in Sonic Slash Sports.
- I'm so fast as the speed of sound. - Sam starting a race in Sonic Riders (series).
- Aaron, this time I'll not obey your orders. - Sam challenging her boss, Aaron, in Sam's Z Mission.
- Prepare yourself, 'cause here comes Sam. - Sam starting a football game in Sonic Soccer's X-Treme.
- Sam is bilingual.
- Sam was called Sonia.
- Sam was afraid of the darkness.
- Sam gets angry easily (her patience running fast).
- She has tanned skin.
- She is a bit sensitive.
- She is very sarcastic.
- Rarely, Sam cries in some cases. Probably by memories of the death of her father, according she has told.
- Sometimes she bothers people for fun.
- Sam can be a kinda jealous.